Immune reconstitution therapy MS focuses on resetting the immune response to reduce disease activity and maintain long-term control rather than continuous suppression.
What is Immune Reconstitution Therapy MS?
This approach consists of treatments aimed at reshaping the immune system through specific or spaced-out doses. These medications reduce the immune cells that cause inflammation, allowing for the formation of a more balanced immune system that does not attack the central nervous system, specifically the brain and spinal cord.
This method differs from traditional therapies in that its effect may last for a long period after the medication is stopped, reducing the patient’s need for daily drug intake.
IRT Treatments for MS
This group includes therapeutic options based on limited time cycles, the most prominent of which are:
- Cladribine (such as Mavenclad): Available as oral tablets taken in treatment cycles that typically last for two years; its therapeutic effect may extend up to 15 years.
- Alemtuzumab: Administered intravenously in spaced doses, and studies have indicated that its effect may last up to 12 years in some cases.
Advantages of Using These Therapies
Using IRT treatments for MS provides several benefits compared to standard disease-modifying therapies (DMTs), including:
- A significant reduction in the number of relapses.
- Slowing or preventing the occurrence of neurological disabilities and disease complications.
- Delaying the deterioration of neurological functions and alleviating symptoms, which improves quality of life.
- Reducing the psychological and physical burden resulting from chronic medication use.
Risks and Treatment Challenges
These medications are not suitable for everyone, as their appropriateness is determined based on the number of relapses, disease activity, and the health status of each individual. Starting this path requires a comprehensive evaluation and detailed discussion with a specialist to balance the desired benefits against potential risks.
FAQ
What is immune based therapy?
It refers to modern medications, such as those used in immune reconstitution, that work by reducing inflammation-causing immune cells to rebuild a better-functioning immune system, rather than permanently suppressing immunity.
Are these medications taken daily?
No, they differ from traditional treatments in that they are given in limited treatment cycles or spaced doses, and their effect remains continuous for a long period.
Who are the candidate patients for this treatment?
The physician determines this based on the patient’s health condition, the level of multiple sclerosis activity, and the frequency of relapses.
When to Visit a Doctor?
You should consult a specialist immediately if warning signs appear, such as:
- Sudden deterioration in vision or sensation.
- New difficulties in movement or balance.
- Decline in cognitive functions or the appearance of unexplained neurological symptoms.
Medical Disclaimer: This content is for informational purposes only and does not substitute for professional medical advice.
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approved by: Medica Health team