Research indicates that gender differences in pain arise from varying biological processes in the body, with females often demonstrating a stronger response to pain.
Why are there gender differences in pain?
A study conducted on mice, with findings generalized to humans, showed that the disparity in pain perception is not due to estrogen, as previously believed. Instead, the secret lies in how the body processes pain through the immune system and the influence of male hormones such as testosterone.
The immune system works in integration with the nervous system to influence the brain, and its role is not limited to fighting infections. Specific immune cells known as “glia” play a pivotal role in this process; when pain is felt, these cells change shape and secrete chemicals that communicate with neurons in the spinal cord, leading to an increased sensation of pain.
Biological differences in pain processing
There are fundamental differences in the response of immune cells between the sexes:
- In males: Biological interventions occur that inhibit the action of glia, reducing the intensity of the pain sensation.
- In females: T cells secrete chemicals that enhance the effect of glial cells, making the pain more intense.
These results emphasize the need to search for therapeutic alternatives that account for these distinctions, as the female response to treatments may differ from that of males.
FAQ
Are female hormones the cause of increased pain?
No, recent studies have indicated that the belief that estrogen is the cause is incorrect, and that the reason lies in biological processing methods and the immune system.
How does the immune system affect the sensation of pain?
Glial cells secrete chemicals that interact with nerves in the spinal cord to increase the feeling of pain, and this process differs between males and females.
Do responses to pain relief treatments differ between genders?
Yes, it is expected that females will respond to treatments differently than males due to the biological differences in how pain is processed.
When should you visit a doctor?
Medical consultation should be sought immediately when the following signs appear:
- Sudden and severe pain that does not respond to standard painkillers.
- Pain spreading to different areas of the body without an obvious cause.
- Impaired ability to move or perform daily activities due to the intensity of the pain.
Disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.
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Illustration: AI-generated
approved by: Medica Health team